Journal article
The emerging association between bronchiectasis and systemic sclerosis: assessing prevalence and potential causality
R Smith, M Harrison, KV Lam, B Adler, M Bulsara, J Sahhar, W Stevens, S Proudman, M Nikpour, E Gabbay
Internal Medicine Journal | WILEY | Published : 2023
DOI: 10.1111/imj.15661
Abstract
Background: Bronchiectasis has been observed in association with systemic sclerosis (SSc). Theorised aetiology includes aspiration related to oesophageal dysmotility, immunosuppressant medication use and the direct effect of collagen deposition on airway calibre. Aims: To detail bronchiectasis prevalence in an SSc population who have had a high-resolution computed tomography (HRCT) of the thorax. We assessed whether oesophageal dysmotility, demographic variables, SSc duration or subclass were associated with bronchiectasis. Methods: Participants in the Australian Scleroderma Cohort Study (ASCS) with a HRCT were included. The ASCS provided demographic and clinical data. HRCT studies were revi..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We acknowledge the ASIG for the establishment and maintenance of the ASCS database, without which this study would not have been possible. Many thanks to the radiology departments of St Vincent's Hospital, Melbourne; Monash Medical Centre, Melbourne and Royal Adelaide Hospital, Adelaide for providing access to the HRCT scans required for this study. We also acknowledge Mr Jack Bendat for his support through the Bendat Respiratory Research and Development Fund. The Australian Scleroderma Interest Group is supported by Scleroderma Victoria and Scleroderma Australia and has received research grants from Janssen, GlaxoSmithKline (GSK), Commonwealth Serum Laboratories (CSL), Australian Rheumatology Association (Arthritis Australia) and St Vincent's Hospital Melbourne Research Endowment Fund.